Restoring Treatment Response in Colorectal Cancer Cells by Targeting MACC1-Dependent ABCB1 Expression in Combination Therapy

Restoring Treatment Response in Colorectal Cancer Cells by Targeting MACC1-Dependent ABCB1 Expression in Combination Therapy

Treatment failure of solid cancers, represented by the development of drug resistance in the primary tumor or later outgrowth of drug resistant metastases, is the major cause of death for cancer patients. It represents an urgent clinical need for predictive biomarkers which indicate the success or f...

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Bibliographic Details
Main Authors: Mathias Dahlmann, Rebecca Werner, Benedikt Kortüm, Dennis Kobelt, Wolfgang Walther, Ulrike Stein
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
MACC1
colorectal cancer
multi-drug resistance
ABCB1
combination therapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00599/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00599/full

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