Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress

Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress

Abstract ACE2 and TMPRSS2 are key players on SARS-CoV-2 entry into host cells. However, it is still unclear whether expression levels of these factors could reflect disease severity. Here, a case–control study was conducted with 213 SARS-CoV-2 positive individuals where cases were defined as COVID-1...

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Main Authors: Átila Duque Rossi, João Locke Ferreira de Araújo, Tailah Bernardo de Almeida, Marcelo Ribeiro-Alves, Camila de Almeida Velozo, Jéssica Maciel de Almeida, Isabela de Carvalho Leitão, Sâmila Natiane Ferreira, Jéssica da Silva Oliveira, Hugo José Alves, Helena Toledo Scheid, Débora Souza Faffe, Rafael Mello Galliez, Renata Eliane de Ávila, Gustavo Gomes Resende, Mauro Martins Teixeira, COVID-19 UFRJ Workgroup, Orlando da Costa Ferreira Júnior, Terezinha Marta P. P. Castiñeiras, Renan Pedra Souza, Amilcar Tanuri, Renato Santana de Aguiar, Shana Priscila Coutinho Barroso, Cynthia Chester Cardoso
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88944-8

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https://doi.org/10.1038/s41598-021-88944-8

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