Notch1 signaling in melanoma cells promoted tumor-induced immunosuppression via upregulation of TGF-β1

Notch1 signaling in melanoma cells promoted tumor-induced immunosuppression via upregulation of TGF-β1

Abstract Background The receptors of Notch family play an important role in controlling the development, differentiation, and function of multiple cell types. The aim of this study is to investigate the role of Notch1 signaling upon immune suppression induced by melanoma cells. Methods Melanoma cell...

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Bibliographic Details
Main Authors: Zike Yang, Yanxia Qi, Nan Lai, Jiahe Zhang, Zehong Chen, Mingyu Liu, Wan Zhang, Rongcheng Luo, Shijun Kang
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Malignant melanoma
Immunotherapy
Immunosuppression
Notch1
TGF-β1
Notch
Online Access:http://link.springer.com/article/10.1186/s13046-017-0664-4

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http://link.springer.com/article/10.1186/s13046-017-0664-4

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