4-(Hydroxymethyl)catechol Extracted From Fungi in Marine Sponges Attenuates Rheumatoid Arthritis by Inhibiting PI3K/Akt/NF-κB Signaling

4-(Hydroxymethyl)catechol Extracted From Fungi in Marine Sponges Attenuates Rheumatoid Arthritis by Inhibiting PI3K/Akt/NF-κB Signaling

Rheumatoid arthritis (RA) is a progressive autoimmune disease specific to synovial joints; it causes joint damage and other systemic abnormalities, thereby leading to physical disability and early mortality. Marine sponge-derived fungi, Pestalotiopsis sp., secrete immunosuppressive compounds in the...

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Bibliographic Details
Main Authors: Jong Y. Lee, Geum J. Kim, Jin K. Choi, Young-Ae Choi, Na-Hee Jeong, Pil-Hoon Park, Hyukjae Choi, Sang-Hyun Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
collagen-induced arthritis
synovial fibroblasts
4-(hydroxymethyl)catechol
Pestalotiopsis
matrix metalloproteinase
inflammatory cytokine
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00726/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00726/full

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