Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility

Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility

Ca2+ influx through Orai1 channels is crucial for several T cell functions, but a role in regulating basal cellular motility has not been described. Here, we show that inhibition of Orai1 channel activity increases average cell velocities by reducing the frequency of pauses in human T cells migratin...

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Bibliographic Details
Main Authors: Tobias X Dong, Shivashankar Othy, Milton L Greenberg, Amit Jairaman, Chijioke Akunwafo, Sabrina Leverrier, Ying Yu, Ian Parker, Joseph L Dynes, Michael D Cahalan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
cell motility
Orai1
genetically encoded Ca2+ indicator
Ca2+ signaling
two-photon microscopy
Online Access:https://elifesciences.org/articles/27827

Internet

https://elifesciences.org/articles/27827

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