Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome

Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome

An unorthodox, surprising mechanism of resistance to the antibiotic linezolid was revealed by cryo-electron microscopy (cryo-EM) in the 70S ribosomes from a clinical isolate of Staphylococcus aureus. This high-resolution structural information demonstrated that a single amino acid deletion in riboso...

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Bibliographic Details
Main Authors: Matthew J. Belousoff, Zohar Eyal, Mazdak Radjainia, Tofayel Ahmed, Rebecca S. Bamert, Donna Matzov, Anat Bashan, Ella Zimmerman, Satabdi Mishra, David Cameron, Hans Elmlund, Anton Y. Peleg, Shashi Bhushan, Trevor Lithgow, Ada Yonath, Gongyi Zhang, Robert A. Bonomo
Format: Article
Language:English
Published: American Society for Microbiology 2017-05-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/8/3/e00395-17

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http://mbio.asm.org/cgi/content/full/8/3/e00395-17

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