Analysis of B Cell Repertoire Dynamics Following Hepatitis B Vaccination in Humans, and Enrichment of Vaccine-specific Antibody Sequences

Analysis of B Cell Repertoire Dynamics Following Hepatitis B Vaccination in Humans, and Enrichment of Vaccine-specific Antibody Sequences

Generating a diverse B cell immunoglobulin repertoire is essential for protection against infection. The repertoire in humans can now be comprehensively measured by high-throughput sequencing. Using hepatitis B vaccination as a model, we determined how the total immunoglobulin sequence repertoire ch...

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Bibliographic Details
Main Authors: Jacob D. Galson, Johannes Trück, Anna Fowler, Elizabeth A. Clutterbuck, Márton Münz, Vincenzo Cerundolo, Claudia Reinhard, Robbert van der Most, Andrew J. Pollard, Gerton Lunter, Dominic F. Kelly
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:EBioMedicine
Subjects:
Vaccination
Immunoglobulin repertoire
B cell repertoire
mAbs
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415302176

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http://www.sciencedirect.com/science/article/pii/S2352396415302176

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