ROS responsive resveratrol delivery from LDLR peptide conjugated PLA-coated mesoporous silica nanoparticles across the blood–brain barrier

ROS responsive resveratrol delivery from LDLR peptide conjugated PLA-coated mesoporous silica nanoparticles across the blood–brain barrier

Abstract Background Oxidative stress acts as a trigger in the course of neurodegenerative diseases and neural injuries. An antioxidant-based therapy can be effective to ameliorate the deleterious effects of oxidative stress. Resveratrol (RSV) has been shown to be effective at removing excess reactiv...

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Bibliographic Details
Main Authors: Yang Shen, Bin Cao, Noah R. Snyder, Kevin M. Woeppel, James R. Eles, Xinyan Tracy Cui
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Nanobiotechnology
Subjects:
Blood–brain barrier (BBB)
Resveratrol (RSV)
Mesoporous silica nanoparticles (MSNPs)
Reactive oxygen species (ROS)
LDLR ligand peptide
Online Access:http://link.springer.com/article/10.1186/s12951-018-0340-7

Internet

http://link.springer.com/article/10.1186/s12951-018-0340-7

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