Bispecific antibodies with Fab-arms featuring exchanged antigen-binding constant domains

Bispecific antibodies with Fab-arms featuring exchanged antigen-binding constant domains

Monoclonal antibodies can acquire the property of engagement of a second antigen via fusion methods or modification of their CDR loops, but also by modification of their constant domains, such as in the mAb2 format where a set of mutated amino acid residues in the CH3 domains enables a high-affinity...

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Bibliographic Details
Main Authors: Filippo Benedetti, Florian Stracke, Gerhard Stadlmayr, Katharina Stadlbauer, Florian Rüker, Gordana Wozniak-Knopp
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Bispecific antibody
Fab constant domain exchange
Domain-exchanged antibody
“Knobs-into-holes” heterodimerization
Her2 internalization
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821000534

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http://www.sciencedirect.com/science/article/pii/S2405580821000534

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