Telomere and Centromere Staining Followed by M-FISH Improves Diagnosis of Chromosomal Instability and Its Clinical Utility

Telomere and Centromere Staining Followed by M-FISH Improves Diagnosis of Chromosomal Instability and Its Clinical Utility

Dicentric chromosomes are a relevant marker of chromosomal instability. Their appearance is associated with telomere dysfunction, leading to cancer progression and a poor clinical outcome. Here, we present Telomere and Centromere staining followed by M-FISH (TC+M-FISH) for improved detection of telo...

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Bibliographic Details
Main Authors: Radhia M’kacher, Bruno Colicchio, Claire Borie, Steffen Junker, Valentine Marquet, Leonhard Heidingsfelder, Kevin Soehnlen, Wala Najar, William M. Hempel, Noufissa Oudrhiri, Nadège Wilhelm-Murer, Marguerite Miguet, Micheline Arnoux, Catherine Ferrapie, Wendy Kerbrat, Andreas Plesch, Alain Dieterlen, Theodore Girinsky, Philippe Voisin, Georges Deschenes, Anne-Claude Tabet, Catherine Yardin, Annelise Bennaceur-Griscelli, Michael Fenech, Patrice Carde, Eric Jeandidier
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Genes
Subjects:
telomere
centromere
dicentric chromosome
chromosomal instability
cancer
genetic syndrome
Online Access:https://www.mdpi.com/2073-4425/11/5/475

Internet

https://www.mdpi.com/2073-4425/11/5/475

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