The WT1/MVP-Mediated Stabilization on mTOR/AKT Axis Enhances the Effects of Cisplatin in Non-small Cell Lung Cancer by a Reformulated Yu Ping Feng San Herbal Preparation

The WT1/MVP-Mediated Stabilization on mTOR/AKT Axis Enhances the Effects of Cisplatin in Non-small Cell Lung Cancer by a Reformulated Yu Ping Feng San Herbal Preparation

Chemo-resistance is an obstacle in therapy of lung cancer. Alternative therapy of using herbal medicine has been proposed to resolve this obstacle. Yu Ping Feng San (YPFS), a common Chinese herbal medicinal mixture, has been reported to show anti-drug resistance on cisplatin (DDP), a common lung can...

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Bibliographic Details
Main Authors: Jian-Shu Lou, Yi-Teng Xia, Huai-You Wang, Xiang-Peng Kong, Ping Yao, Tina T. X. Dong, Zhong-Yu Zhou, Karl W. K. Tsim
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
non-small cell lung cancer
MVP
mTORC2
WT1
herbal medicine
chemo-resistance
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00853/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00853/full

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