Effects of Immunization With the Soil-Derived Bacterium Mycobacterium vaccae on Stress Coping Behaviors and Cognitive Performance in a “Two Hit” Stressor Model

Effects of Immunization With the Soil-Derived Bacterium Mycobacterium vaccae on Stress Coping Behaviors and Cognitive Performance in a “Two Hit” Stressor Model

Previous studies demonstrate that Mycobacterium vaccae NCTC 11659 (M. vaccae), a soil-derived bacterium with anti-inflammatory and immunoregulatory properties, is a potentially useful countermeasure against negative outcomes to stressors. Here we used male C57BL/6NCrl mice to determine if repeated i...

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Bibliographic Details
Main Authors: Christine L. Foxx, Jared D. Heinze, Antonio González, Fernando Vargas, Michael V. Baratta, Ahmed I. Elsayed, Jessica R. Stewart, Kelsey M. Loupy, Mathew R. Arnold, M. C. Flux, Saydie A. Sago, Philip H. Siebler, Lauren N. Milton, Margaret W. Lieb, James E. Hassell, David G. Smith, Kyo A. K. Lee, Sandra A. Appiah, Evan J. Schaefer, Morgan Panitchpakdi, Nicole C. Sikora, Kelly C. Weldon, Christopher E. Stamper, Dominic Schmidt, David A. Duggan, Yosan M. Mengesha, Mikale Ogbaselassie, Kadi T. Nguyen, Chloe A. Gates, K’loni Schnabel, Linh Tran, Joslynn D. Jones, Martha H. Vitaterna, Fred W. Turek, Monika Fleshner, Pieter C. Dorrestein, Rob Knight, Kenneth P. Wright, Christopher A. Lowry
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Physiology
Subjects:
cognition
diurnal
locomotor activity
metabolome
microbiome
microbiome-gut-brain axis
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.524833/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.524833/full

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