Effective normalization for copy number variation in Hi-C data

Effective normalization for copy number variation in Hi-C data

Abstract Background Normalization is essential to ensure accurate analysis and proper interpretation of sequencing data, and chromosome conformation capture data such as Hi-C have particular challenges. Although several methods have been proposed, the most widely used type of normalization of Hi-C d...

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Bibliographic Details
Main Authors: Nicolas Servant, Nelle Varoquaux, Edith Heard, Emmanuel Barillot, Jean-Philippe Vert
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Bioinformatics
Subjects:
Normalization
Hi-C
Cancer
Copy-number
Online Access:http://link.springer.com/article/10.1186/s12859-018-2256-5

Internet

http://link.springer.com/article/10.1186/s12859-018-2256-5

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