Notoginsenoside R1 Improves Cerebral Ischemia/Reperfusion Injury by Promoting Neurogenesis via the BDNF/Akt/CREB Pathway

Notoginsenoside R1 Improves Cerebral Ischemia/Reperfusion Injury by Promoting Neurogenesis via the BDNF/Akt/CREB Pathway

Notoginsenoside R1 (R1), a major component isolated from P. notoginseng, is a phytoestrogen that exerts many neuroprotective effects in a rat model of ischemic stroke. However, its long-term effects on neurogenesis and neurological restoration after ischemic stroke have not been investigated. The ai...

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Bibliographic Details
Main Authors: Ting Zhu, Lei Wang, Weijie Xie, Xiangbao Meng, Yicheng Feng, Guibo Sun, Xiaobo Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
ischemic stroke
notoginsenoside R1
neurogenesis
neurological recovery
oligodendrogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.615998/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.615998/full

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