Age influences susceptibility of brain capillary endothelial cells to La Crosse virus infection and cell death

Age influences susceptibility of brain capillary endothelial cells to La Crosse virus infection and cell death

Abstract Background A key factor in the development of viral encephalitis is a virus crossing the blood-brain barrier (BBB). We have previously shown that age-related susceptibility of mice to the La Crosse virus (LACV), the leading cause of pediatric arbovirus encephalitis in the USA, was associate...

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Bibliographic Details
Main Authors: Rahul Basu, Vinod Nair, Clayton W. Winkler, Tyson A. Woods, Iain D. C. Fraser, Karin E. Peterson
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Neuroinflammation
Subjects:
Brain capillary endothelial cells
Blood-brain barrier
Cytopathic effect
La Crosse virus
Vascular leakage
Online Access:https://doi.org/10.1186/s12974-021-02173-4

Internet

https://doi.org/10.1186/s12974-021-02173-4

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