HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice.

CryAB (HspB5) and HspB2, two small heat shock genes located adjacently in the vertebrate genome, are hypothesized to play distinct roles. Mice lacking both cryab and hspb2 (DKO) are viable and exhibit adult-onset degeneration of skeletal muscle but confounding results from independent groups were re...

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Bibliographic Details
Main Authors: Takahiro Ishiwata, András Orosz, Xiaohui Wang, Soumyajit Banerjee Mustafi, Gregory W Pratt, Elisabeth S Christians, Sihem Boudina, E Dale Abel, Ivor J Benjamin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3411653?pdf=render