Predictive network modeling in human induced pluripotent stem cells identifies key driver genes for insulin responsiveness.

Predictive network modeling in human induced pluripotent stem cells identifies key driver genes for insulin responsiveness.

Insulin resistance (IR) precedes the development of type 2 diabetes (T2D) and increases cardiovascular disease risk. Although genome wide association studies (GWAS) have uncovered new loci associated with T2D, their contribution to explain the mechanisms leading to decreased insulin sensitivity has...

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Bibliographic Details
Main Authors: Ivan Carcamo-Orive, Marc Y R Henrion, Kuixi Zhu, Noam D Beckmann, Paige Cundiff, Sara Moein, Zenan Zhang, Melissa Alamprese, Sunita L D'Souza, Martin Wabitsch, Eric E Schadt, Thomas Quertermous, Joshua W Knowles, Rui Chang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-12-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1008491

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https://doi.org/10.1371/journal.pcbi.1008491

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