Dihydrosphingosine driven enrichment of sphingolipids attenuates TGFβ induced collagen synthesis in cardiac fibroblasts

Dihydrosphingosine driven enrichment of sphingolipids attenuates TGFβ induced collagen synthesis in cardiac fibroblasts

The sphingolipid de novo synthesis pathway, encompassing the sphingolipids, the enzymes and the cell membrane receptors, are being investigated for their role in diseases and as potential therapeutic targets. The intermediate sphingolipids such as dihydrosphingosine (dhSph) and sphingosine (Sph) hav...

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Bibliographic Details
Main Authors: Ruth R. Magaye, Feby Savira, Xin Xiong, Kevin Huynh, Peter J. Meikle, Christopher Reid, Bernard L. Flynn, David Kaye, Danny Liew, Bing H. Wang
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:International Journal of Cardiology: Heart & Vasculature
Subjects:
Cardiac fibroblasts
Collagen synthesis
Dihydrosphingosine
Sphingolipid
TGFβ
Online Access:http://www.sciencedirect.com/science/article/pii/S2352906721001251

Internet

http://www.sciencedirect.com/science/article/pii/S2352906721001251

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