Tanshinone IIA attenuates Aβ-induced neurotoxicity by down-regulating COX-2 expression and PGE2 synthesis via inactivation of NF-κB pathway in SH-SY5Y cells

Tanshinone IIA attenuates Aβ-induced neurotoxicity by down-regulating COX-2 expression and PGE2 synthesis via inactivation of NF-κB pathway in SH-SY5Y cells

Abstract Amyloid-β (Aβ)-induced neurotoxicity is a major pathological mechanism of Alzheimer’s disease (AD). Tanshinone IIA (Tan IIA), extracted from traditional Chinese herb Radix salvia miltiorrhiza, possesses anti-oxidant and anti-inflammatory actions, as well as neuroprotective effects. The pres...

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Bibliographic Details
Main Authors: Lijiao Geng, Wei Liu, Yong Chen
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Biological Research - Thessaloniki
Subjects:
Tanshinone IIA
Amyloid-β
COX-2
PGE2
NF-κB pathway
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s40709-019-0102-1

Internet

http://link.springer.com/article/10.1186/s40709-019-0102-1

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