The ratio 1660/1690 cm(-1) measured by infrared microspectroscopy is not specific of enzymatic collagen cross-links in bone tissue.

In postmenopausal osteoporosis, an impairment in enzymatic cross-links (ECL) occurs, leading in part to a decline in bone biomechanical properties. Biochemical methods by high performance liquid chromatography (HPLC) are currently used to measure ECL. Another method has been proposed, by Fourier Tra...

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Main Authors: Delphine Farlay, Marie-Eve Duclos, Evelyne Gineyts, Cindy Bertholon, Stéphanie Viguet-Carrin, Jayakrupakar Nallala, Ganesh D Sockalingum, Dominique Bertrand, Thierry Roger, Daniel J Hartmann, Roland Chapurlat, Georges Boivin
Format: Article
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
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