<i>iNOS</i> Gene Ablation Prevents Liver Fibrosis in Leptin-Deficient <i>ob/ob </i>Mice

<i>iNOS</i> Gene Ablation Prevents Liver Fibrosis in Leptin-Deficient <i>ob/ob </i>Mice

<i>iNOS</i> deficiency in <i>ob/ob</i> mice improved liver inflammation and ECM remodeling-related genes, decreasing fibrosis, and metabolic dysfunction. The activation of iNOS by leptin is necessary for the synthesis and secretion of TNC in hepatocytes, suggesting an importa...

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Bibliographic Details
Main Authors: Sara Becerril, Amaia Rodríguez, Victoria Catalán, Beatriz Ramírez, Xabier Unamuno, Javier Gómez-Ambrosi, Gema Frühbeck
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Genes
Subjects:
Leptin, iNOS, Tenascin C, liver fibrosis, inflammation
Online Access:https://www.mdpi.com/2073-4425/10/3/184

Internet

https://www.mdpi.com/2073-4425/10/3/184

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