Molecular mechanisms by which HERV-K Gag interferes with HIV-1 Gag assembly and particle infectivity

Molecular mechanisms by which HERV-K Gag interferes with HIV-1 Gag assembly and particle infectivity

Abstract Background Human endogenous retroviruses (HERVs), the remnants of ancient retroviral infections, constitute approximately 8% of human genomic DNA. Since HERV-K Gag expression is induced by HIV-1 Tat in T cells, induced HERV-K proteins could affect HIV-1 replication. Indeed, previously we sh...

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Bibliographic Details
Main Authors: Kazuaki Monde, Hiromi Terasawa, Yusuke Nakano, Ferri Soheilian, Kunio Nagashima, Yosuke Maeda, Akira Ono
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Retrovirology
Subjects:
HIV-1
HERV-K
Gag coassembly
Online Access:http://link.springer.com/article/10.1186/s12977-017-0351-8

Internet

http://link.springer.com/article/10.1186/s12977-017-0351-8

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