Cadmium exposure induces rat proximal tubular cells injury via p62-dependent Nrf2 nucleus translocation mediated activation of AMPK/AKT/mTOR pathway

Cadmium exposure induces rat proximal tubular cells injury via p62-dependent Nrf2 nucleus translocation mediated activation of AMPK/AKT/mTOR pathway

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a nuclear transcription factor of great concern which is widely involved in physiological and pathological processes of the organism, but the role and regulatory mechanism of Nrf2 in kidney exposed to cadmium (Cd) remain largely unknown. Here we...

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Bibliographic Details
Main Authors: Wenxuan Dong, Gang Liu, Kanglei Zhang, Yun Tan, Hui Zou, Yan Yuan, Jianhong Gu, Ruilong Song, Jiaqiao Zhu, Zongping Liu
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Cadmium
Oxidative stress
Autophagy
Kidney
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S014765132100169X

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http://www.sciencedirect.com/science/article/pii/S014765132100169X

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