Abnormal Mitochondrial Function and Impaired Granulosa Cell Differentiation in Androgen Receptor Knockout Mice

Abnormal Mitochondrial Function and Impaired Granulosa Cell Differentiation in Androgen Receptor Knockout Mice

In the ovary, the paracrine interactions between the oocyte and surrounded granulosa cells are critical for optimal oocyte quality and embryonic development. Mice lacking the androgen receptor (AR−/−) were noted to have reduced fertility with abnormal ovarian function that might involve the promotio...

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Bibliographic Details
Main Authors: Ruey-Sheng Wang, Heng-Yu Chang, Shu-Huei Kao, Cheng-Heng Kao, Yi-Chen Wu, Shuyuan Yeh, Chii-Reuy Tzeng, Chawnshang Chang
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:International Journal of Molecular Sciences
Subjects:
androgen receptor
granulosa cell
PGC1-β
mitochondria
Online Access:http://www.mdpi.com/1422-0067/16/5/9831

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http://www.mdpi.com/1422-0067/16/5/9831

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