Abnormal Mitochondrial Function and Impaired Granulosa Cell Differentiation in Androgen Receptor Knockout Mice
In the ovary, the paracrine interactions between the oocyte and surrounded granulosa cells are critical for optimal oocyte quality and embryonic development. Mice lacking the androgen receptor (AR−/−) were noted to have reduced fertility with abnormal ovarian function that might involve the promotio...
Main Authors: | Ruey-Sheng Wang, Heng-Yu Chang, Shu-Huei Kao, Cheng-Heng Kao, Yi-Chen Wu, Shuyuan Yeh, Chii-Reuy Tzeng, Chawnshang Chang |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2015-04-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/16/5/9831 |
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