ß1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion.

ß1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion.

Extracellular matrix (ECM) degradation is a critical process in tumor cell invasion and requires matrix degrading protrusions called invadopodia. The Na(+)/H(+) exchanger (NHE1) has recently been shown to be fundamental in the regulation of invadopodia actin cytoskeleton dynamics and activity. Howev...

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Bibliographic Details
Main Authors: Ester Antelmi, Rosa A Cardone, Maria R Greco, Rosa Rubino, Francesca Di Sole, Nicola A Martino, Valeria Casavola, Marialuisa Carcangiu, Loredana Moro, Stephan J Reshkin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24086451/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24086451/?tool=EBI

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