Discovery of Potent Disheveled/Dvl Inhibitors Using Virtual Screening Optimized With NMR-Based Docking Performance Index

Discovery of Potent Disheveled/Dvl Inhibitors Using Virtual Screening Optimized With NMR-Based Docking Performance Index

Most solid tumors have their own cancer stem cells (CSCs), which are resistant to standard chemo-therapies. Recent reports have described that Wnt pathway plays a key role in self-renewal and tumorigenesis of CSCs. Regarding the Wnt/β-catenin pathway, Dvl (mammalian Disheveled) is an attractive targ...

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Bibliographic Details
Main Authors: Kiminori Hori, Kasumi Ajioka, Natsuko Goda, Asako Shindo, Maki Takagishi, Takeshi Tenno, Hidekazu Hiroaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
Wnt signaling
protein–protein interaction inhibitor
NMR-derived docking performance index
virtual screening
triple negative breast cancer
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00983/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00983/full

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