Hematopoietic Stem Cells Are Intrinsically Protected against MLL-ENL-Mediated Transformation

Hematopoietic Stem Cells Are Intrinsically Protected against MLL-ENL-Mediated Transformation

Studies of developmental pathways of hematopoietic stem cells (HSCs) have defined lineage relationships throughout the blood system. This is relevant to acute myeloid leukemia (AML), where aggressiveness and therapeutic responsiveness can be influenced by the initial stage of transformation. To addr...

Full description

Bibliographic Details
Main Authors: Amol Ugale, Gudmundur L. Norddahl, Martin Wahlestedt, Petter Säwén, Pekka Jaako, Cornelis Jan Pronk, Shamit Soneji, Jörg Cammenga, David Bryder
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471400905X

Internet

http://www.sciencedirect.com/science/article/pii/S221112471400905X

Similar Items