PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim

PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim

Abstract Background Protein kinase C theta, (PRKCQ/PKCθ) is a serine/threonine kinase that is highly expressed in a subset of triple-negative breast cancers (TNBC) and promotes their growth, anoikis resistance, epithelial-mesenchymal transition (EMT), and invasion. Here, we show that PRKCQ regulates...

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Bibliographic Details
Main Authors: Jessica H. Byerly, Elisa R. Port, Hanna Y. Irie
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Breast Cancer Research
Subjects:
PRKCQ
Bim
Apoptosis
Triple-negative breast cancer
Online Access:http://link.springer.com/article/10.1186/s13058-020-01302-w

Internet

http://link.springer.com/article/10.1186/s13058-020-01302-w

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