Cell Penetrable Human scFv Specific to Middle Domain of Matrix Protein-1 Protects Mice from Lethal Influenza

Cell Penetrable Human scFv Specific to Middle Domain of Matrix Protein-1 Protects Mice from Lethal Influenza

A new anti-influenza remedy that can tolerate the virus antigenic variation is needed. Influenza virus matrix protein-1 (M1) is highly conserved and pivotal for the virus replication cycle: virus uncoating, assembly and budding. An agent that blocks the M1 functions should be an effective anti-influ...

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Bibliographic Details
Main Authors: Fonthip Dong-din-on, Thaweesak Songserm, Tippawan Pissawong, Potjanee Srimanote, Jeeraphong Thanongsaksrikul, Kanyarat Thueng-in, Pattra Moonjit, Preeda Lertwatcharasarakul, Watee Seesuay, Wanpen Chaicumpa
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Viruses
Subjects:
Cell penetrating antibody
H5N1
human ScFv
influenza
influenza virus
matrix protein-1 (M1)
middle domain of M1
molecular docking
phage display
transbody
Online Access:http://www.mdpi.com/1999-4915/7/1/154

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http://www.mdpi.com/1999-4915/7/1/154

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