Identification of irisin as a therapeutic agent that inhibits oxidative stress and fibrosis in a murine model of chronic pancreatitis

Identification of irisin as a therapeutic agent that inhibits oxidative stress and fibrosis in a murine model of chronic pancreatitis

Background: Abnormal activation of pancreatic stellate cells (PSCs) plays a crucial role in the pathogenesis of chronic pancreatitis (CP). Irisin, an exercise-induced hormone, has been shown to mitigate liver fibrosis by inhibiting the activation of hepatic stellate cells. However, the effect of iri...

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Bibliographic Details
Main Authors: Yifan Ren, Jia Zhang, Mengzhou Wang, Jianbin Bi, Tao Wang, Minglong Qiu, Yi Lv, Zheng Wu, Rongqian Wu
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Chronic pancreatitis
Stellate cell
Irisin
Fibrosis
Oxidative stress
ER stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220302936

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http://www.sciencedirect.com/science/article/pii/S0753332220302936

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