Current View in Platinum Drug Mechanisms of Peripheral Neurotoxicity

Current View in Platinum Drug Mechanisms of Peripheral Neurotoxicity

Peripheral neurotoxicity is the dose-limiting factor for clinical use of platinum derivatives, a class of anticancer drugs which includes cisplatin, carboplatin, and oxaliplatin. In particular cisplatin and oxaliplatin induce a severe peripheral neurotoxicity while carboplatin is less neurotoxic. Th...

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Bibliographic Details
Main Authors: Alessia Chiorazzi, Sara Semperboni, Paola Marmiroli
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Toxics
Subjects:
platinum drugs
peripheral neurotoxicity
mechanisms of action
Online Access:http://www.mdpi.com/2305-6304/3/3/304

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