Indomethacin Increases the Efficacy of Oxygen Utilization of Colonic Mitochondria and Uncouples Hepatic Mitochondria in Tissue Homogenates From Healthy Rats

Indomethacin Increases the Efficacy of Oxygen Utilization of Colonic Mitochondria and Uncouples Hepatic Mitochondria in Tissue Homogenates From Healthy Rats

Background: Studies suggest that indomethacin (Indo) exhibits detrimental changes in the small intestine (microvascular disorder, villus shortening, and epithelial disruption), mainly due to mitochondrial uncoupling. The effects of Indo on colon and liver tissue are unclear. The aim of this study wa...

Full description

Bibliographic Details
Main Authors: Anna Herminghaus, Albert J. Buitenhuis, Jan Schulz, Richard Truse, Christian Vollmer, Borna Relja, Inge Bauer, Olaf Picker
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Medicine
Subjects:
indomethacin
mitochondrial function
colon
liver
adverse event
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2020.00463/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2020.00463/full

Similar Items