Effects of the ABCB1 (1199G > A) Polymorphism on Steroid Sex Hormone-Induced P-Glycoprotein Expression, ATPase Activity, and Hormone Efflux

Effects of the ABCB1 (1199G > A) Polymorphism on Steroid Sex Hormone-Induced P-Glycoprotein Expression, ATPase Activity, and Hormone Efflux

This study examined how the 1199G > A polymorphism in the ABCB1 gene encoding P-glycoprotein (P-gp) affects the protein’s expression, ATPase activity, and ability to pump female steroid sex hormones out of LLC-PK1 cells. The ABCB1 (1199G) or ABCB1 (1199A) allele was transfected into cells, wh...

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Bibliographic Details
Main Authors: Rui Peng, Hong Zhang, Ying Zhang, Dan-Yun Wei
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Medical Sciences
Subjects:
ABCB1 (1199G &gt
A)
polymorphism
P-gp
steroid sex hormone
transport
Online Access:http://www.mdpi.com/2076-3271/3/4/124

Internet

http://www.mdpi.com/2076-3271/3/4/124

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