Effects of the ABCB1 (1199G > A) Polymorphism on Steroid Sex Hormone-Induced P-Glycoprotein Expression, ATPase Activity, and Hormone Efflux
This study examined how the 1199G > A polymorphism in the ABCB1 gene encoding P-glycoprotein (P-gp) affects the protein’s expression, ATPase activity, and ability to pump female steroid sex hormones out of LLC-PK1 cells. The ABCB1 (1199G) or ABCB1 (1199A) allele was transfected into cells, wh...
Main Authors: | Rui Peng, Hong Zhang, Ying Zhang, Dan-Yun Wei |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2015-12-01
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Series: | Medical Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/2076-3271/3/4/124 |
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