Reciprocal allosteric modulation of carbon monoxide and warfarin binding to ferrous human serum heme-albumin.

Reciprocal allosteric modulation of carbon monoxide and warfarin binding to ferrous human serum heme-albumin.

Human serum albumin (HSA), the most abundant protein in human plasma, could be considered as a prototypic monomeric allosteric protein, since the ligand-dependent conformational adaptability of HSA spreads beyond the immediate proximity of the binding site(s). As a matter of fact, HSA is a major tra...

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Bibliographic Details
Main Authors: Alessio Bocedi, Giampiero De Sanctis, Chiara Ciaccio, Grazia R Tundo, Alessandra Di Masi, Gabriella Fanali, Francesco P Nicoletti, Mauro Fasano, Giulietta Smulevich, Paolo Ascenzi, Massimo Coletta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3605432?pdf=render

Internet

http://europepmc.org/articles/PMC3605432?pdf=render

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