DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions

DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions

Translation efficiency can be affected by mRNA stability and secondary RNA structures. Here the authors reveal that loss of DHX36 helicase activity leads to an accumulation of translationally inactive target mRNAs with G-rich structures in untranslated regions.

Bibliographic Details
Main Authors: Markus Sauer, Stefan A. Juranek, James Marks, Alessio De Magis, Hinke G. Kazemier, Daniel Hilbig, Daniel Benhalevy, Xiantao Wang, Markus Hafner, Katrin Paeschke
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10432-5

Internet

https://doi.org/10.1038/s41467-019-10432-5

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