DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions

Translation efficiency can be affected by mRNA stability and secondary RNA structures. Here the authors reveal that loss of DHX36 helicase activity leads to an accumulation of translationally inactive target mRNAs with G-rich structures in untranslated regions.

Bibliographic Details
Main Authors:	Markus Sauer, Stefan A. Juranek, James Marks, Alessio De Magis, Hinke G. Kazemier, Daniel Hilbig, Daniel Benhalevy, Xiantao Wang, Markus Hafner, Katrin Paeschke
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-10432-5

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spelling	doaj-c487ca0e9f33481f9ed1636cdf7e8cc92021-05-11T12:01:28ZengNature Publishing GroupNature Communications2041-17232019-06-0110111510.1038/s41467-019-10432-5DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regionsMarkus Sauer0Stefan A. Juranek1James Marks2Alessio De Magis3Hinke G. Kazemier4Daniel Hilbig5Daniel Benhalevy6Xiantao Wang7Markus Hafner8Katrin Paeschke9Department of Biochemistry, Biocenter, University of WürzburgDepartment of Oncology, Hematology and Rheumatology, University Hospital BonnLaboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIHDepartment of Oncology, Hematology and Rheumatology, University Hospital BonnEuropean Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, University of GroningenDepartment of Oncology, Hematology and Rheumatology, University Hospital BonnLaboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIHLaboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIHLaboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIHDepartment of Biochemistry, Biocenter, University of WürzburgTranslation efficiency can be affected by mRNA stability and secondary RNA structures. Here the authors reveal that loss of DHX36 helicase activity leads to an accumulation of translationally inactive target mRNAs with G-rich structures in untranslated regions.https://doi.org/10.1038/s41467-019-10432-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Markus Sauer Stefan A. Juranek James Marks Alessio De Magis Hinke G. Kazemier Daniel Hilbig Daniel Benhalevy Xiantao Wang Markus Hafner Katrin Paeschke
spellingShingle	Markus Sauer Stefan A. Juranek James Marks Alessio De Magis Hinke G. Kazemier Daniel Hilbig Daniel Benhalevy Xiantao Wang Markus Hafner Katrin Paeschke DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions Nature Communications
author_facet	Markus Sauer Stefan A. Juranek James Marks Alessio De Magis Hinke G. Kazemier Daniel Hilbig Daniel Benhalevy Xiantao Wang Markus Hafner Katrin Paeschke
author_sort	Markus Sauer
title	DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions
title_short	DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions
title_full	DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions
title_fullStr	DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions
title_full_unstemmed	DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions
title_sort	dhx36 prevents the accumulation of translationally inactive mrnas with g4-structures in untranslated regions
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-06-01
description	Translation efficiency can be affected by mRNA stability and secondary RNA structures. Here the authors reveal that loss of DHX36 helicase activity leads to an accumulation of translationally inactive target mRNAs with G-rich structures in untranslated regions.
url	https://doi.org/10.1038/s41467-019-10432-5
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DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions

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