A reason why the <it>ERBB2 </it>gene is amplified and not mutated in breast cancer
<p>Abstract</p> <p>Alterations of receptor-type tyrosine kinases (RTK) are frequent in human cancers. They can result from translocation, mutation or amplification. The ERBB2 RTK is encoded by a gene that is amplified in about 20% breast cancers. The question is: why is this RTK sp...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-02-01
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| Series: | Cancer Cell International |
| Online Access: | http://www.cancerci.com/content/9/1/5 |