Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms.

African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host, but it is unknown whether either process is essential to the parasite.Pyrimidine requirements for growth were investigated using strictly pyrimidine-free media, with or without single...

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Bibliographic Details
Main Authors: Juma A M Ali, Daniel N A Tagoe, Jane C Munday, Anne Donachie, Liam J Morrison, Harry P de Koning
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3591441?pdf=render