Diabetes Secondary to Acromegaly: Physiopathology, Clinical Features and Effects of Treatment

Diabetes Secondary to Acromegaly: Physiopathology, Clinical Features and Effects of Treatment

Acromegaly is a rare disease due to chronic GH excess and to the consequent increase in IGF-1 levels. Both GH and IGF-1 play a role in intermediate metabolism affecting glucose homeostasis. Indeed, chronic GH excess impairs insulin sensitivity, increases gluconeogenesis, reduces the glucose uptake i...

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Bibliographic Details
Main Authors: Francesco Ferraù, Adriana Albani, Alessandro Ciresi, Carla Giordano, Salvatore Cannavò
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Endocrinology
Subjects:
acromegaly
diabetes
GH
IGF-1
pituitary tumor
glucose metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00358/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2018.00358/full

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