Enhanced differentiation of human induced pluripotent stem cells toward the midbrain dopaminergic neuron lineage through GLYPICAN‐4 downregulation

Enhanced differentiation of human induced pluripotent stem cells toward the midbrain dopaminergic neuron lineage through GLYPICAN‐4 downregulation

Abstract Enhancing the differentiation potential of human induced pluripotent stem cells (hiPSC) into disease‐relevant cell types is instrumental for their widespread application in medicine. Here, we show that hiPSCs downregulated for the signaling modulator GLYPICAN‐4 (GPC4) acquire a new biologic...

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Bibliographic Details
Main Authors: Serena Corti, Remi Bonjean, Thomas Legier, Diane Rattier, Christophe Melon, Pascal Salin, Erik A. Toso, Michael Kyba, Lydia Kerkerian‐Le Goff, Flavio Maina, Rosanna Dono
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Stem Cells Translational Medicine
Subjects:
GLYPICAN‐4
hiPSCs
hPSC‐derived dopaminergic neurons
intrastriatal transplantation
self‐renewal and differentiation
Online Access:https://doi.org/10.1002/sctm.20-0177

Internet

https://doi.org/10.1002/sctm.20-0177

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