Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests

Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests

Standard approaches for heritability and set testing in statistical genetics rely on parametric models that might not hold in reality and give inflated p-values. Here, the authors develop a fast method for permutation-based testing of marker sets and of heritability that does not suffer from model m...

Full description

Bibliographic Details
Main Authors: Regev Schweiger, Eyal Fisher, Omer Weissbrod, Elior Rahmani, Martina Müller-Nurasyid, Sonja Kunze, Christian Gieger, Melanie Waldenberger, Saharon Rosset, Eran Halperin
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07276-w

Internet

https://doi.org/10.1038/s41467-018-07276-w

Similar Items