Rhein sensitizes human pancreatic cancer cells to EGFR inhibitors by inhibiting STAT3 pathway

Rhein sensitizes human pancreatic cancer cells to EGFR inhibitors by inhibiting STAT3 pathway

Abstract Background Rhein is a lipophilic anthraquinone extensively found in medicinal herbs. Emerging evidence suggests that rhein has significant antitumor effects, supporting its potential use as an antitumor agent. The IL6/STAT3 signaling pathway has been suggested as an attractive target for th...

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Bibliographic Details
Main Authors: Lehe Yang, Shichong Lin, Yanting Kang, Youqun Xiang, Lingyuan Xu, Jifa Li, Xuanxuan Dai, Guang Liang, Xiaoying Huang, Chengguang Zhao
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Rhein
Pancreatic cancer
STAT3
EGFR
Inhibitor
Online Access:http://link.springer.com/article/10.1186/s13046-018-1015-9

Internet

http://link.springer.com/article/10.1186/s13046-018-1015-9

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