LRRK2 and Protein Aggregation in Parkinson’s Disease: Insights From Animal Models

LRRK2 and Protein Aggregation in Parkinson’s Disease: Insights From Animal Models

Mutations in leucine-rich repeat kinase 2 (LRRK2) instigate an autosomal dominant form of Parkinson’s disease (PD). Despite the neuropathological heterogeneity observed in LRRK2-PD, accumulating evidence suggests that alpha-synuclein and tau pathology are observed in a vast majority of cases. Intrig...

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Bibliographic Details
Main Authors: Dylan J. Dues, Darren J. Moore
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Neuroscience
Subjects:
Parkinson’s disease
LRRK2
tau
alpha-synuclein
protein aggregation
neurodegeneration
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00719/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00719/full

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