miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy

miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy

Abstract Background Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first and rate-limiting step in converting tryptophan to kynurenine. Chimeric antigen receptor (CAR) T cells are T cells with recombinant receptors targeting tumor-associated antigens. The Food and Drug Administration has approve...

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Bibliographic Details
Main Authors: Qian Huang, Jiajia Xia, Lei Wang, Xu Wang, Xiaodong Ma, Qipan Deng, Yong Lu, Munish Kumar, Zhiyuan Zhou, Ling Li, Zhaoyang Zeng, Ken H. Young, Qing Yi, Mingzhi Zhang, Yong Li
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Hematology & Oncology
Subjects:
Chimeric antigen receptor (CAR)
T cells
Indoleamine 2,3-dioxygenase 1 (IDO1)
miR-153
Colon cancer
Tumor microenvironment
Online Access:http://link.springer.com/article/10.1186/s13045-018-0600-x

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http://link.springer.com/article/10.1186/s13045-018-0600-x

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