Synthesis of Dihydrouracils Spiro-Fused to Pyrrolidines: Druglike Molecules Based on the 2-Arylethyl Amine Scaffold

Synthesis of Dihydrouracils Spiro-Fused to Pyrrolidines: Druglike Molecules Based on the 2-Arylethyl Amine Scaffold

The synthesis of a small library of dihydrouracils spiro-fused to pyrrolidines is described. These compounds are synthesized from b-aryl pyrrolidines, providing products with the 2-arylethyl amine moiety, a structural feature often encountered in compounds active in the central nervous system. The b...

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Bibliographic Details
Main Authors: Daniel Blanco-Ania, Carolina Valderas-Cortina, Pedro H.H. Hermkens, Leo A.J.M. Sliedregt, Hans W. Scheeren, Floris P.J.T. Rutjes
Format: Article
Language:English
Published: MDPI AG 2010-03-01
Series:Molecules
Subjects:
Knoevenagel condensation
1,3-dipolar cycloaddition
azomethine ylide
parallel synthesis
spiro dihydrouracils
Online Access:http://www.mdpi.com/1420-3049/15/4/2269/

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http://www.mdpi.com/1420-3049/15/4/2269/

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