Electrophysiological mechanisms of Brugada syndrome: insights from pre-clinical and clinical studies

Electrophysiological mechanisms of Brugada syndrome: insights from pre-clinical and clinical studies

Brugada syndrome (BrS), is a primary electrical disorder predisposing affected individuals to sudden cardiac death via the development of ventricular tachycardia and fibrillation (VT/VF). Originally, BrS was linked to mutations in the SCN5A, which encodes for the cardiac Na+ channel. To date, varian...

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Bibliographic Details
Main Authors: Gary Tse, Ka Hou Christien Li, Victoria Laxton, Yin Wah Fiona Chan, Wendy Keung, Ronald A Li, Bryan P Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Physiology
Subjects:
Brugada Syndrome
arrhythmia
Sodium channel
Repolarization
risk stratification
Depolarization
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00467/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00467/full

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