An implantable vascularized protein gel construct that supports human fetal hepatoblast survival and infection by hepatitis C virus in mice.

An implantable vascularized protein gel construct that supports human fetal hepatoblast survival and infection by hepatitis C virus in mice.

Widely accessible small animal models suitable for the study of hepatitis C virus (HCV) in vivo are lacking, primarily because rodent hepatocytes cannot be productively infected and because human hepatocytes are not easily engrafted in immunodeficient mice.We report here on a novel approach for huma...

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Bibliographic Details
Main Authors: Martha J Harding, Christin M Lepus, Thomas F Gibson, Benjamin R Shepherd, Scott A Gerber, Morven Graham, Frank X Paturzo, Christoph Rahner, Joseph A Madri, Alfred L M Bothwell, Brett D Lindenbach, Jordan S Pober
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2848675?pdf=render

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http://europepmc.org/articles/PMC2848675?pdf=render

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