FM-CATH, A Novel Cathelicidin From Fejervarya Multistriata, Shows Therapeutic Potential for Treatment of CLP-Induced Sepsis

FM-CATH, A Novel Cathelicidin From Fejervarya Multistriata, Shows Therapeutic Potential for Treatment of CLP-Induced Sepsis

Sepsis is an exacerbated inflammatory reaction induced by severe infection. As important defensive molecules in innate immunity, several AMPs are reported to prevent septic shock. In this study, we characterized a novel cathelicidin, FM-CATH, from the frog skin of F. multistriata. FM-CATH was found...

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Bibliographic Details
Main Authors: Jiena Wu, Haiyun Zhang, Xiaoxin Chen, Jinwei Chai, Yunrui Hu, Weichen Xiong, Wancheng Lu, Maolin Tian, Xin Chen, Xueqing Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
antimicrobial peptide
cathelicidin
sepsis
lipopolysaccharide and lipoteichoic acid-neutralizing
coagulation
cecal ligation and puncture
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.731056/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.731056/full

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